Our new publication is now available online.
Abstract: We report the on-resin synthesis of monodisperse (i.e. discrete) polysarcosine compounds and their uses as an hydrophobicity masking entity for the construction of highly-loaded homogeneous antibody-drug conjugates (ADC). The polysarcosine-based drug-linker platform described herein improves drug-loading, physicochemical properties, pharmacokinetics and shows excellent potency in vivo.
Read more about this publication on ChemRxiv.